The Guadalupe on Main

The Guadalupe on Main Family owned modern southwest cusine with flavors from Jalisco Mexico. Craft cocktails and mixology is our specialty.
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Relaxing and colorful atmosphere will make it hard to leave.

🔥 NEW CHEF’S SPECIALS ARE HERE 🔥And Chef Jhomeny is putting his spin on pork belly tacosCrispy pork belly + avocado crem...
08/21/2026

🔥 NEW CHEF’S SPECIALS ARE HERE 🔥

And Chef Jhomeny is putting his spin on pork belly tacos

Crispy pork belly + avocado crema + tamarindo glaze + pickled red onion + cilantro + salsa macha crumble, all tucked into fresh 50/50 blue & yellow corn tortillas

Plus, the return of our crispy breaded wings with a new Korean Red sauce and an Ube Cookie Skillet for dessert.
Because one course is never enough. 😉

Swipe ➡️ to see Chef bring those tacos to life.

Chef’s Specials | Available while supplies last

This Thursday August 20thMusic Bingo returns from 7-9pmHosted by ColbyFREE TO PLAY
08/17/2026

This Thursday August 20th
Music Bingo returns from 7-9pm
Hosted by Colby
FREE TO PLAY

1/2 price wings on Wednesdays!
08/12/2026

1/2 price wings on Wednesdays!

Chef's Specials | 8/5–8/9The people have spoken... so wings are back for another week! Choose your sauce: 🔥 Brown Butter...
08/06/2026

Chef's Specials | 8/5–8/9

The people have spoken... so wings are back for another week!
Choose your sauce: 🔥 Brown Butter Piloncillo Chile de Árbol 🌿 Garlic Cilantro Mojo 🤎 Mole

New this week: Chef Jhomeny's Tacos al Pastor and Coconut Flan (dairy free)

Chef's Specials are available while supplies last

Which one are you trying first?

07/31/2026

🚨 This weekend only 🚨
We would like to thank everyone that voted for our chef Jhomeny Ramos in PHOENIX magazine best of the valley readers choice!
This weekend we will be celebrating by giving away 1 free order of our gluten free churros per table!
All you have to do is like, comment, & reshare this post!
Show your server or bartender the video when ordering & we will take care of the churros.
Must be following us on instagram to receive the free order. 1 order per table.
Awards we took home
Phoenix Magazine
-Best Chef - 2026
-Best Mexican Restaurant - 2025/2026
-Best New Restaurant - 2025
AZ New Times
-Best Margaritas- 2025

Join us August 10th to watch our latest bartender battle.
07/25/2026

Join us August 10th to watch our latest bartender battle.

Now offering gluten free hamburger buns made locally by Arizona Gluten free bakeryThese buns are the real deal! Super bu...
07/24/2026

Now offering gluten free hamburger buns made locally by Arizona Gluten free bakery
These buns are the real deal! Super buttery flavor! Our smash-burger made with piloncillo bacon, sautéed green chile and onion, lettuce, cowboy aioli, and Arizona Gluten free bakery Brioche handmade buns made with gluten free flower!

Monday August 10th 2026 the Guadalupe will be hosting a bartender competition. Please come support your favorite bartend...
07/17/2026

Monday August 10th 2026 the Guadalupe will be hosting a bartender competition. Please come support your favorite bartenders as they face off head to head representing their bars!

07/14/2026
We think it’s safe to say that Music Bingo was a hit! Thank you DJ Cold Beef 🥩 and thank you to everyone that played. Ke...
07/11/2026

We think it’s safe to say that Music Bingo was a hit! Thank you DJ Cold Beef 🥩 and thank you to everyone that played. Keep a lookout we will try it again next month!
Colby
djcoldbeef

Address

1526 E Main Street
Mesa, AZ
85204

Opening Hours

Wednesday 11am - 10pm
Thursday 11am - 10pm
Friday 11am - 11pm
Saturday 11am - 11pm
Sunday 11am - 9pm

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